Details about broadly neutralizing antibodies provide insights for universal flu vaccine

ScienceDaily | Oct 23, 2020 at 8:02 PM
  • The study, published October 22 in Immunity, explores the behavior of polyreactive antibodies — antibodies that are capable of binding to more than one distinct antigen — in an effort to understand their role against influenza viruses.
  • The research is inspired by the limited efficacy of the annual flu vaccine, which must be adjusted each year to provide the best protection against commonly circulating strains of the virus, and why it so rarely induces broadly neutralizing antibodies.
  • Polyreactive antibodies are therefore ideal candidates for developing a universal flu vaccine — one that can not only protect against common annual strains, but also novel influenza viruses, like the H1N1 strain seen during the 2009 pandemic.